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An ill-defined mixed density lesion (peripheral hyperdense/solid and central hypodense/cystic/necrotic components) is seen in the left temporoparietal region adjacent to the temporal horn & atrium of the left lateral ventricle. The lesion is involving the splenium of the corpus callosum and extending through it to the right side of the midline. The peripheral hyperdense/solid components show mild enhancement on the post-contrast scan. This space-occupying lesion is likely a high-grade glioma (e.g. glioblastoma multiforme). Another possible differential diagnosis is CNS lymphoma.
Two cortical/subcortical hypodensities are seen in the left parieto-occipital and left posterior frontal regions, which are likely old watershed infarcts.