Pathology
Gross pathology
200x H&E
200x H&E
200x Synaptophysin (SYN)
200x Glial fibrillary acidic protein (GFAC)
Gross pathology image shows the macroscopic appearance of the lesion (black arrows).
Hematoxylin-eosin (H&E) stains show multiple small round blue cells within a neuropil-like matrix, forming rosette aggregates. Some calcifications can be observed at the superior and inferior right quadrants of the second picture (big irregular violet structures). There are also small disperse vessels. In the third picture, a few hemosiderin deposits can be seen at the superior left quadrant (brown small irregular forms). No chondroid matrix could be appreciated.
The fourth picture shows diffuse and intense synaptophysin (SYN) positivity.
The last picture demonstrates negativity for glial fibrillary acidic protein (GFAC) stain.
Inmunohystochemical analysis also revealed an absence of IDH mutations or 1p19q co-deletion.