How does this radiopharmaceutical localize to the target?
Metaiodobenzylguanidine (MIBG) is a norepinephrine analog that is taken up in the pre-synaptic, adrenergic, neuron granules by the norepinephrine transporter.
What are the primary sites of uptake for MIBG?
Salivary glands, lacrimal glands, thyroid glands, adrenal glands, heart, liver, spleen, kidneys, bladder, small and large bowel
Anterior and posterior whole body planar images from the I-123 MIBG scan demonstrate an oval focus of intense uptake overlying the left kidney (best seen on posterior views). Otherwise normal MIBG uptake pattern.