Azygos anterior cerebral artery

Case contributed by Safwat Mohammad Almoghazy
Diagnosis certain

Presentation

Recurrent headache migraine-like and associated with nausea.

Patient Data

Age: 45 years
Gender: Female

An incidentally noted fused or join the left and right A1 segments to form a single trunk making an azygos anterior cerebral artery (rare normal variant), before branching into normal branches. 

Otherwise, no evidence of abnormal signal intensity. 

Case Discussion

An azygos anterior cerebral artery is an uncommon-to-rare variant of the circle of Willis where the two A1 segments of the anterior cerebral artery (ACA) join to form a single trunk. As a result, there is no anterior communicating artery

The clinical importance of an azygos artery:

  • it may be associated with a number of brain anomalies such as dysgenesis of corpus callosum and holoprosencephaly, and a predisposition to aneurysm formation
  • occlusion of an azygos artery may result in infarcts of the bilateral medial frontal lobes and corpus callosum

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