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This moderate regional volume loss of the frontal lobes bilaterally, right worse than left, slightly more pronounced than previously. Mild volume loss of the left temporal lobe. The remainder of the cerebral volume is within normal limits for age. Bilateral frontal reduced relative cerebral blood flow on ASL perfusion.
Mild periventricular white matter hyperintensity is likely due to mild chronic small vessel disease.
No high FLAIR signal along the corticospinal tracts to suggest imaging features of motor neuron disease.
Conclusion: Slightly progressed frontal lobe volume loss since the previous study, compatible with the given diagnosis of frontotemporal dementia. No imaging features of motor neuron disease.