Wilson disease
Updates to Case Attributes
Symmetrical hyperintensityhyperintensities involving the caudate head, putamen, and thalamus waswere noted. On USGultrasound correlation, liver cirrhosis was observed.KF. Kayser-Fleischer ring visualized on examining the eye.
Sometimes the high signal intensity is noted in tegmentum with preservation of substantial nigra and red nucleus signal giving rise to the Faceface of the giant panda sign is seen, however, this sign is not present in our case.
Differential diagnoses for the MRI brain findings are Leigh disease and pantothenate kinase-associated neurodegeneration (PKAN).
-<p>Symmetrical hyperintensity involving the caudate head, putamen, and thalamus was noted. On USG correlation liver cirrhosis was observed.KF ring visualized on examining the eye.</p><p>Sometimes the high signal intensity is noted in tegmentum with preservation of substantial nigra and red nucleus signal giving rise to <a href="/articles/face-of-the-giant-panda-sign-midbrain">Face of the giant panda sign (midbrain)</a>. However, this sign is not present in our case.</p><p>Differential diagnoses are <a href="/articles/leigh-syndrome-3">Leigh disease</a> and <a href="/articles/pantothenate-kinase-associated-neurodegeneration">PKAN</a>. </p>- +<p>Symmetrical hyperintensities involving the caudate head, putamen, and thalamus were noted. On ultrasound correlation, liver cirrhosis was observed. Kayser-Fleischer ring visualized on examining the eye.</p><p>Sometimes the high signal intensity is noted in tegmentum with preservation of substantial nigra and red nucleus signal giving rise to the <a href="/articles/face-of-the-giant-panda-sign-midbrain">face of the giant panda sign</a> is seen, however, this sign is not present in our case.</p><p>Differential diagnoses for the MRI brain findings are <a href="/articles/leigh-syndrome-3">Leigh disease</a> and <a title="Pantothenate kinase-associated neurodegeneration (PKAN)" href="/articles/pantothenate-kinase-associated-neurodegeneration">pantothenate kinase-associated neurodegeneration (PKAN)</a>. </p>
References changed:
- 2. Yu X, Gao S, Yang R, Han Y. MR Imaging of the Brain in Neurologic Wilson Disease. AJNR Am J Neuroradiol. 2019;40(1):178-83. <a href="https://doi.org/10.3174/ajnr.A5936">doi:10.3174/ajnr.A5936</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30635331">Pubmed</a>
- Yu X, Gao S, Yang R, Han Y. MR Imaging of the Brain in Neurologic Wilson Disease. AJNR Am J Neuroradiol. 2019;40(1):178-83. <a href="https://doi.org/10.3174/ajnr.a5936">doi:10.3174/ajnr.a5936</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30635331">Pubmed</a>
Systems changed:
- Hepatobiliary
Updates to Study Attributes
Symmetrical hyperintensity is noted in the bilateral caudate head, putamen, and thalamus on TT2/FLAIR showing no restriction on DWI/ADC.
Updates to Study Attributes
Kayser-Fleischer ringsring is present.