Acute Marchiafava-Bignami disease

Case contributed by Dr Vahe Michael Zohrabian


Chronic alcoholic with acute headache and disorientation

Patient Data

Age: 45 years
Gender: Female

ASNR 2016: This case was submitted as part of the American Society of Neuroradiology (ASNR 2016) Case Of The Day competition, in collaboration with 

There is focal low T1 and high T2/FLAIR signal with restricted diffusion in the splenium of the corpus callosum. There is no associated mass effect.

Case Discussion

The patient was treated with intravenous vitamin B complex, with complete resolution of her symptoms over the course of several weeks.

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Case information

rID: 42904
Published: 14th Feb 2016
Last edited: 21st Aug 2020
Inclusion in quiz mode: Included

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