Acute Marchiafava-Bignami disease
45 year old chronic alcoholic female presenting with acute headache and disorientation.
ASNR 2016: This case was submitted as part of the American Society of Neuroradiology (ASNR 2016) Case Of The Day competition, in collaboration with Radiopaedia.org.
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There is focal low T1 and high T2/FLAIR signal with restricted diffusion in the splenium of the corpus callosum. There is no associated mass effect.
The patient was treated with intravenous vitamin B complex, with complete resolution of her symptoms over the course of several weeks.
- 1. Arbelaez A, Pajon A, Castillo M. Acute Marchiafava-Bignami disease: MR findings in two patients. AJNR Am J Neuroradiol. 2004;24 (10): 1955-7. Pubmed citation