Adamantinomatous craniopharyngioma

Case contributed by Assoc Prof Frank Gaillard

Patient Data

Age: Adult
Gender: Male

CT brain


Suprasellar mass, predominantly of intermediate to fluid attenuation without convincing calcification.

MRI pituitary


Selected sagittal and coronal pre and post contrast images demonstrate a multicystic/solid mass in the suprasellar region, with intrinsic high T1 signal. 

Case Discussion

The patient went on to have a resection.


The section shows a single small fragment of tissue. This is composed of irregularly shaped islands of mature squamous epithelium which are dispersed in a loose fibrous stroma. These show strong immunostaining  for cytokeratins AE1/AE3 and CAM5.2. The stroma contains aggregates of keratin. Focal foreign-body type granulomatous inflammation in association with some collections of keratin are noted. There is also focal dystrophic calcification. No cyst formation is seen. The features are those of a craniopharyngioma.


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