Adrenal lymphoma

Case contributed by Dr James Harvey

Presentation

Chronic abdominal pain. GP requested CT abdomen demonstrated adrenal lesions. The patient was referred to hospital for further evaluation. No history of primary malignancy. No infectious symptoms.

Patient Data

Age: 65 years
Gender: Male
CT

Large bilateral soft-tissue density adrenal lesions. No internal fat or calcification.

LEFT ADRENAL LESION
Pre-contrast: 33 HU
Portal venous contrast: 59 HU
15 minute delayed: 58 HU
Absolute washout: 3.8%
Relative washout: 1.7%

RIGHT ADRENAL LESION
Pre-contrast: 28 HU
Portal venous contrast: 33 HU
15 minute delayed: 30 HU
Absolute washout: 60%
Relative washout: 9.1%

The washout characteristics were indeterminate. Size > 4cm is concerning for malignancy, including metastases or bilateral adrenal cortical carcinomas.

Nuclear medicine

FDG-PET/CT

Bilateral large FDG avid adrenal lesions with numerous surrounding malignant FDG avid lymph nodes near the upper abdominal aorta and IVC. No evidence of metastatic disease elsewhere.  

The most likely etiology was considered bilateral adrenal metastases with metastatic lymph nodes in the upper abdomen, but a primary malignancy was not identified. 

Synchronous primary adrenal carcinomas with adjacent metastatic nodes was considered possible.

CT

CT-guided biopsy

Left adrenal biopsy: High grade B cell lymphoma, consistent with diffuse large
B cell lymphoma (DLBCL), non-germinal center B (GCB) subtype.

Case Discussion

Following the histology, bone marrow aspiration was performed which was also consistent with DLBCL.

Primary adrenal lymphoma is a rare entity. Secondary involvement of the adrenal glands is more common.

PlayAdd to Share

Case information

rID: 73730
Published: 21st Jan 2020
Last edited: 21st Jan 2020
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.