Case contributed by Dr Salman S. Albakheet


History of seizures and visual disturbance.

Patient Data

Age: Child
Gender: Male

MRI Brain

There is evidence of bilateral symmetrical confluent low Tl signal and high T2 signal involving peritrigonal white matter, optic radiation as well as splenium and extending to involve the corticospinal tracts. The subcortical U-fiber white matter is spared.  The "leading edge" also demonstrates enhancement after Gadolinium injection.  Additionally there is bilateral symmetrical auditory pathways involvement at the level of brain stem (pons) with enhancement after contrast injection. 

Case Discussion

These MRI features are typical for X-linked adrenoleukodystrophy and the diagnosis of this case was confirmed.

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Case information

rID: 33377
Published: 9th Jan 2015
Last edited: 21st Nov 2019
Inclusion in quiz mode: Included