Change in behavior, and learning difficulty at school
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Axial MRI sequences show symmetrical peritrigonal white matter lesion which is hypointense on T1-weighted imaging and hyperintense on T2WI/FLAIR sequences, which also involves the splenium of the corpus callosum, as well as the cerebral peduncles and cerebellar white matter.
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Adrenoleukodytrophy is an inherited peroxisomal disorder, resulting in accumulation of very long chain fatty acids (VLCFAs) in the white matter which causes severe inflammatory demyelination.
X-linked adrenoleukodystrophy is the most common single protein or enzyme deficiency disease to present in childhood, almost seen exclusively in boys age 5-12 years, and has a posterior-predominant pattern.
- Osborn's Brain, Imaging, Pathology and Anatomy by Anne G. Osborn
- Diagnostic Imaging: Brain 2nd Edition by Anne G. Osborn