Enlarged head and hydrocephalus suspected clinically.
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There is absence of normal midline structures and most of the parietal and posterior cortex. Small frontal cortex is present, with no evidence of midline fissure.
The thalami are fused and a large monoventricle and a larger dorsal cyst are present. Cerebellum and brainstem appear within normal limits
The imaging findings (which were also suspected on the antenatal ultrasound) are typical of alobar holoprosencephaly.
- 1. Huibers M, Papatsonis DN. Prenatal diagnosis of alobar holoprosencephaly, by use of ultrasound and magnetic resonance imaging in the second trimester. J. Matern. Fetal. Neonatal. Med. 2009;22 (12): 1204-6. doi:10.3109/14767050902994721 - Pubmed citation
- 2. Sawhney S, Machado L, Jain R. Prenatal MRI image of a fetus with semilobar holoprosencephaly. Sultan Qaboos Univ Med J. 2011;8 (1): 93-4. Free text at pubmed - Pubmed citation