Alzheimer disease or LATE

Case contributed by Frank Gaillard
Diagnosis probable


Memory probelms.

Patient Data

Age: 75 years
Gender: Male

There is mild generalized cerebral volume loss without particular lobar predominance. Bilateral hippocampal atrophy is demonstrated, more than the degree of the cerebral volume loss elsewhere, more so on the left side (ERICA score = 2 on the right and = 3 on the left). There is mild chronic small vessel ischemic change. No hydrocephalus. No space-occupying lesion. No abnormal susceptibility to suggest cerebral amyloid angiopathy. No abnormal diffusion restriction. The remainder of the brain is unremarkable.


In this clinical context, findings are compatible with Alzheimer's disease or limbic-predominant age-related TDP-43 encephalopathy (LATE).

Case Discussion

Unfortunately at this time, there are no additional tests (e.g. amyloid PET or CSF) available to help distinguish between the two entities. 

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