Amiodarone lung

Case contributed by Dr David Pryde


73 year old female presenting with SOB.

Patient Data

Age: 73
Gender: Female
Modality: X-ray

Patchy widespread lung infiltrates and previous cardiac surgery.

Modality: CT

Multiple patchy bilateral areas of lung consolidation tending towards the periphery with an occasional groundless area consistent with organising pneumonia.

Dense liver also - not shown.

Biopsy proven.

Case Discussion

Organising pneumonia (OP) is considered a non-specific repair process in lungs in response to various kinds of lung insults:

  • cryptogenic organising pneumonia (COP) when the cause is not known
  • secondary organising pneumonia when the cause is known
    • infection, inflammatory bowel disease, drugs (as in the above case), collagen vascular disease, organ transplantation and radiation direct to the chest

The histological hallmark of OP is intra-alveolar granulation tissue plugs (Masson bodies) which extend into bronchiolar lumina. The presence of these plugs is a prerequisite for restoration of tissue integrity.

Not to be confused with Bronchiolitis Obliterans Organising Pneumonia (BOOP), which is a disease specifically of small airways

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Case Information

rID: 38994
Case created: 15th Aug 2015
Last edited: 10th Dec 2016
System: Chest
Inclusion in quiz mode: Included

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