Amyloidoma - mediastinal

Case contributed by Dr Natalie Yang
  • Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

Large lobulated mediastinal mass with calcifications extending into the right thorax. This mass is also compressing the trachea. Right pleural effusion noted.

Case Discussion

Final Diagnosis: Mediastinal amyloidoma

Right chest mass, core biopsy - amyloid with areas of focal calcification and an otherwise acellular specimen.


Immunohistochemical stains for kappa and lambda are non contributory as there are insufficient plasma cells for staining. Congo Red stains show that the material is apple green birefringent when viewed under polarized light. EM shows the charecteristic beta pleated sheets of amyloid.

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Case information

rID: 6711
Published: 9th Aug 2009
Last edited: 20th Apr 2021
System: Oncology, Chest
Tag: amyloid
Inclusion in quiz mode: Included