Amyotrophic lateral sclerosis
Adult patient with weakness.
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MRI demonstrates prominent T2 signal in the corticospinal tracts as well as somewhat reduced signal intensity in the precentral gyrus.
These features, although subtle were thought to be consistent with and support the clinical and EMG diagnosis of amyotrophic lateral sclerosis.
It is important to note that both these features are seen faintly in many normal subjects and thus an appreciation for what is 'normal' is essential.