Amyotrophic lateral sclerosis
Progressive lower limb weakness and speech difficulty for 2 years.
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MR reveals symmetrical hyperintense signal on T2WI and FLAIR involving the bilateral precentral gyri and descending through the corticospinal tracts in the posterior limb of the internal capsule, brainstem, and medulla. No diffusion restriction is present.
Findings most suggestive of amyotrophic lateral sclerosis (ALS).
Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by the selective involvement of the motor neurons.