Amyotrophic lateral sclerosis

Case contributed by Dr Ayaz Hidayatov

Presentation

Progressive lower limb weakness and speech difficulty for 2 years.

Patient Data

Age: 40 years
Gender: Male
MRI

MR reveals symmetrical hyperintense signal on T2WI and FLAIR involving the bilateral precentral gyri and descending through the corticospinal tracts in the posterior limb of the internal capsule, brainstem, and medulla. No diffusion restriction is present.

Findings most suggestive of amyotrophic lateral sclerosis (ALS). 

Case Discussion

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by the selective involvement of the motor neurons. 

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