Anal adenocarcenoma, tumour regression grade 1 post chemoradiotherapy

Case contributed by Dr Jan Frank Gerstenmaier

Presentation

Anal adenocarcinoma pre- and post chemoradiotherapy.

Patient Data

Age: 60 years
Gender: Female

INITIAL BIOPSY

CLINICAL NOTES:

Ulcerated anal skin tag.
3/12 Hx of pain/PR bleeding -> biopsies.

MACROSCOPIC DESCRIPTION:

"Unlabelled as to site":  Multiple fragments of soft tan and cream
tissue 1-4mm.  A1.  (SEK)

MICROSCOPIC DESCRIPTION:

The section shows a polypoid epithelial lesion composed of tubular and
villous structures lined by a stratified arrangement of pleomorphic
columnar epithelial cells. These have enlarged round, oval and
angulated hyperchromatic and vesicular nuclei and a small amount of
eosinophilic cytoplasm. Occasional mitotic figures are identified.
Irregularly shaped glandular structures are seen to extend into
connective tissue at the base of the lesion. Similar irregularly
shaped glandular structures are also present within the lamina propria
of the larger accompanying fragment of squamous mucosa. No
lymphovascular or perineurial invasion is seen. The features are of
moderately differentiated adenocarcinoma arising in a severely
dysplastic tubulovillous adenoma.

DIAGNOSIS:

Anal skin:  Moderately differentiated adenocarcinoma arising in
            a severely dysplastic tubulovillous adenoma.

MR Anal Cancer Staging

Multiplanar noncontrast small field of view MR imaging of the pelvis has been obtained.

An anal polypoid lesion identified, extending down from the left anal mucosa.

This measures 3.8 cm in length. Within the distal half of the anal canal, this lesion involves the mucosa at the 1-2

o'clock position, just touching the internal sphincter. The external sphincter is normal and the intersphincteric plane is preserved. The mesorectum and rectum appear normal.

There are no abnormal inguinal lymph nodes. Visible bones are unremarkable. A 1.5 centimetre uterine leiomyoma is shown. In addition, there is increased endometrial thickness at 1.4 centimetres with small cystic spaces within, is seen in previous CT.

Conclusion:

Low anal canal lesion from the left side, probably just involving internal sphincter at the 1-2 o'clock position superficially at the level of the anal verge (T2). No external sphincter or intersphincteric fat plane involvement identified. No inguinal lymphadenopathy.

Endometrial abnormality suspicious for malignancy, requires further evaluation.

FDG-avid anal mass. No evidence of metastases.

CT

Staging CT pre- and post chemoradiotherapy

Pre and post chemoradiotherapy.

FOLLOW UP BIOPSY AFTER CHEMORADIATION

CLINICAL NOTES:

Peri-anal skin Bx - 3 o'clock.
Subcutaneous anal tissue - 3 o'clock.
61 y/o F with PHx anal adenoCa treated with chemo + XRT for rebiopsy.

MACROSCOPIC DESCRIPTION:

1. "Perianal skin 3 o'clock":  A polypoid fragment of tan tissue 10mm.
                               Bisected.  A1.

2. "Subcutaneous tissue 3 o'clock":  A fragment of fibrous tissue 8mm.
                                     A1.  (SWB)


MICROSCOPIC DESCRIPTION:

1. Sections show squamous mucosa with normal maturation. The lamina
propria is moderately fibrotic with a chronic inflammatory infiltrate
and occasional dilated vessels.  There is no evidence of dysplasia or
an invasive malignancy.

2. Sections show fibrous and fatty tissue with a small amount of
squamous epithelium. There is no evidence of dyplasia or of an
invasive malignancy.


DIAGNOSIS:

1. Perianal skin, 3 o'clock:  Benign squamous mucosa.

2. Subcutaneous tissue 3 o'clock: Benign fibrofatty tissue

Comparison is made with the previous examination. At the site of the previously identified anal lesion, no clearly viable residual tumour is identified. At the point of previously identified contact with the internal sphincter at the 3 o'clock position, there is a 17.7 x 2.3 x 11.6 mm lesion with no definite high T2 signal identified to suggest active tumour identified. Previously the lesion measured 25.5 x 5.9 x 20 mm. The rectum and anal sphincters appears normal.

Since previous, the endometrial thickness has normalised. 1.5 centimetre posterior loops of uterine leiomyoma is again noted.

Conclusion: Apparent excellent tumour response with significant reduction in size and no definite residual tumour signal (mrTRG 1).

Case Discussion

The majority of anal carcinomas are keratinising or basaloid, e.g squamous cell carcinoma. Anal adenocarcinoma is rare. Associations include chronic fistula-in-ano, anal Crohn disease, and anal sexual intercourse.

See reference 1 for details of tumour regression grading.

This case contains the complete workup including initial biopsy result, staging MR, PET/CT and CT, as well as follow up biopsy result, re-stating MR and CT.

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Case information

rID: 31358
Case created: 3rd Oct 2014
Last edited: 13th Mar 2016
Inclusion in quiz mode: Included

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