Anaplastic astrocytoma: IDH wild-type

Case contributed by Matthew Lund
Diagnosis almost certain

Presentation

Confusion, memory problems, and visual deficit

Patient Data

Age: 90 years
Gender: Male

Heterogeneously enhancing right occipital mass with central hemorrhagic foci. A punctate focus of enhancement separate from the main portion of the mass may reflect the infiltrative nature of the mass. Given the close association with and scalloping of the adjacent ventricular margin, there may be malignant involvement of the ventricle. There is also prominent parieto-occipital vasogenic edema involving the right half of the splenium of the corpus callosum.

Case Discussion

The surgical pathology report from excision of the right parieto-occipital tumor showed a diffusely infiltrating glial neoplasm composed of small round to oval atypical astrocytic cells confirmed to be a wild type astrocytoma WHO Grade 3.

On imaging there appear to be macroscopic areas of necrosis which, if present, would make this an under-graded glioblastoma. 

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