Anaplastic astrocytoma NOS

Case contributed by Dr Juan José Gómez Muga

Presentation

Subacute cognitive decline. Dizziness.

Patient Data

Age: 65 years
Gender: Male
CT

Hypodense left hemispheric lesion with mass effect. Midline shift, sulcal effacement and right lateral ventricle effacement. No enhancement with contrast.

MRI

Left temporoinsular lesion with mass effect. High signal on T2 and FLAIR sequences. No diffusion restriction. In the lateral margin there is a focal area of enhancement with increased rCBV on perfusion weighted images.

Case Discussion

Stereotactic biopsy was performed. Histology confirmed the diagnosis of anasplastic astrocytoma (WHO grade III).

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumors, this tumor would, therefore, be designated as an anaplastic astrocytoma NOS.

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