Anaplastic ependymoma (histology)
Posterior fossa tumour.
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Cellular tumor with prominent nuclear pleomorphism and numerous cells undergoing mitosis (bottom right corner) as well as apoptosis. Perivascular pseudorosettes (Figure 2) are present with endothelial hyperplasia. This is an immunohistochemically confirmed ependymoma. Aforementioned features warrant a designation of anaplastic ependymoma, although the clinical significance of this is uncertain.
Case courtesy of Associate Professor Renate Kalnins.