Revision 14 for 'Anaplastic ganglioglioma'

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This is a differential diagnosis case of a temporal lobe cystic lesion in a young adult.

There are a few relevant entities one must consider when encountering a lesion of this appearance in this age group:

1. Ganglioneuroma: Fully differentiated neural tumors, 60% occurring below the age of 20 years1, can demonstrate solid and cystic components as well as fine, speckled calcification.

2. Ganglioglioma: Although primarily occurs in pediatric population, the incidence in young adults is higher than that of ganglioneuroma.

3. Pilocytic astrocytoma: Occuring mostly in pediatric age group, 60% are found in cerebellum with optic nerve, hypothalamus and brain stem consisting most of the other 40%. The location of the lesion in this case is somewhat unusual for a pilocytic astroocytoma.

4. DNET: Mostly occuring in temporal lobes of young people, this is a relevant consideration in this case.

5. Cystic metastasis: Cystic metastasis with mural nodule is the last but not least differential for this lesion. 


Histopathology result:

Anaplastic ganglioglioma with high grade glial component resembling glioblastoma (WHO grade 3). 



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