Anaplastic oligodendroglioma NOS
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Right high frontal intra axial lesion with marginal enhancement
The patient went on to have a resection.
Sections show brain tissue infiltrated by a glial tumour that displays oligodendroglial features. Tumour infiltration into adjacent brain tissue is represented by subpial infiltration, focally prominent neuronal satellitosis and linear profiles of tumour cells. Perivascular infiltration by tumour cells is also observed. In the more cellular areas, the tumour cells display characteristic oligodendroglial features. Mitotic activity is increased in areas. Very focal vascular neogenesis is noted, represented by focal proliferation of endothelial cells. Tumour necrosis is not seen.
Final Diagnosis: anaplastic oligodendroglioma
Note: This case predates the recent (2016) revision WHO classification of CNS tumours, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumour would now be classified as an anaplastic oligodendroglioma NOS.