Anaplastic oligodendroglioma NOS

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: adult

Right high frontal intra axial lesion with marginal enhancement

Case Discussion

The patient went on to have a resection. 

Histology

Microscopic Description:

Sections show brain tissue infiltrated by a glial tumour that displays oligodendroglial features. Tumour infiltration into adjacent brain tissue is represented by subpial infiltration, focally prominent neuronal satellitosis and linear profiles of tumour cells. Perivascular infiltration by tumour cells is also observed. In the more cellular areas, the tumour cells display characteristic oligodendroglial features. Mitotic activity is increased in areas. Very focal vascular neogenesis is noted, represented by focal proliferation of endothelial cells. Tumour necrosis is not seen.

Final Diagnosis: anaplastic oligodendroglioma

Note: This case predates the recent (2016) revision WHO classification of CNS tumours, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumour would now be classified as an anaplastic oligodendroglioma NOS.

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Case information

rID: 6034
Case created: 9th Apr 2009
Last edited: 20th May 2017
Inclusion in quiz mode: Included

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