Case contributed by Osama M. Zaid
Diagnosis certain


Pregnant Female referred for her third-trimester ultrasound scan (~ 35 weeks gestation).

Patient Data

Age: 30 years
Gender: Female

On sonographic evaluation, a single viable intra-uterine fetus is clearly seen. Calvaria and brain tissues were not visualized.

Coronal view of fetal face shows bulging eyes with absence of frontal bones, known as the frog eye sign, which is pathognomonic for anencephaly.

GA corresponds to +/- 34 weeks by measuring femur length (FL).

Associating marked polyhydramnios was also noted, AFI measures about 58 cm.

Case Discussion

Anencephaly can be diagnosed using real-time ultrasonography. In this case of anencephaly, the sonographic findings are so striking as they are diagnosed in a third-trimester pregnancy and are not compatible with life.

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