Angiomatous meningioma

Case contributed by A.Prof Frank Gaillard

Presentation

Headache.

Patient Data

Age: 65 years
Gender: Male
MRI

There is a large enhancing left parafalcine mass. The mass abuts the anterior falx  and the superior sagittal sinus, with possible small extensions of the tumour into the superior sagittal sinus but no compelling evidence of occlusion.

There are small cysts at the interface of the mass with the adjacent brain and multiple parasitised vessels inferior to the mass. There is moderate adjacent mass effect and mild midline shift.

Case Discussion

The appearances were felt to most likely represent a meningioma, although the very high T2 signal is not typical and suggests a histological variant. The variants that usually are T2 hyperintense are microcystic,  secretory, cartilaginous (metaplastic) chordoid and angiomatous. 

The patient went on to have surgery. 

Histology

MICROSCOPIC DESCRIPTION: Paraffin sections show an intensely vascular tumour in which thin-walled vascular spaces of varying calibre are interspersed between small aggregates of cells with round and oval hyperchromatic nuclei and a variable amount of pale cytoplasm. No mitotic figures or areas of necrosis are seen. Attachment to meninges is noted. No evidence of brain invasion is seen. Immunohistochemistry shows strong immunostaining for epithelial membrane antigen (EMA) and vimentin in tumour cells as well as strong nuclear staining for progesterone receptor (PgR) in a moderate number of tumour cells. 

FINAL DIAGNOSIS: Angiomatous meningioma.

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Case information

rID: 42307
Case created: 15th Jan 2016
Last edited: 19th Jun 2016
Inclusion in quiz mode: Included

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