Worsening dyspnoea in a 51 year-old male patient known to have anti-synthetase syndrome.
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HRCT imaging performed in the prone position shows bilateral peripheral and basal regions of ground glass opacification in a peribronchial distribution, with mild architectural distortion, representing organising pneumonia presentation of pulmonary involvement in a patient with antisynthetase syndrome (Anti-JO-1 Ab positive)
Autoimmune inflammatory myositis which commonly has pulmonary involvement with interstitial lung disease (ILD).
Constellation of clinical findings including hand deformity (mechanic's hands), Raynaud's phenomenon and polyarthritis.
The pattern of ILD can be NSIP, organising pneumonia or UIP, with a basal and peripheral distribution, which responds to steroid therapy.
Patient's can develop pulmonary hypertension.
- Pulmonary manifestations of anti-synthetase syndrome: a pictorial review to aid diagnosis and monitoring. Kudari M, et al. Educational Exhibit, European Society of Radiology. ECR 2014. Poster No: C-1273