Apical non-small-cell lung cancer

Case contributed by A.Prof Frank Gaillard

Chest radiographs

Right apical spiculated mass tenting the pleura. 


CT Chest (selected images)

Right upper lobe apical mass invading the adjacent chest wall. 

Case Discussion

Diagnosis of large-cell bronchogenic carcinoma (non-small cell carcinoma, not otherwise specified (NOS)).

Pathology: High-grade large-cell undifferentiated carcinoma located in the apical segment and measuring 2.5 cm in maximum dimension showing radiation/chemotherapy effect. Tumor extends into the overlying chest wall. The tumor is almost entirely necrotic with only small islands of viable tumor cells remaining, (approximately 10% of the tumor appears viable).

Surrounding lung parenchyma shows changes consistent with chemotherapy and radiation, namely interstitial fibrosis, intimal fibrosis and inflammation of the interstitium.

Prominent centrilobular emphysema is present with subpleural blebs and bullae.

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Case information

rID: 8570
Published: 13th Feb 2010
Last edited: 5th Jan 2019
System: Chest
Tag: lung
Inclusion in quiz mode: Included

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