Astrocytoma, IDH-mutant

Case contributed by Frank Gaillard



Patient Data

Age: 35 years
Gender: Male

A left frontal region of low density is present with mass effect. A small curvilinear region of increased density is noted, which is of uncertain significance. 


A large left frontal mass is demonstrated without enhancement, calcification, necrosis or hemorrhage. 

Features favor a diffuse low grade glioma. 

Case Discussion

The patient went on to have surgery.


The sections show features of a moderately cellular astrocytic tumor. The tumor cells have elongated, angulated and hyperchromatic nuclei. Some gemistocytes are noted, occupying about 5% of the cell population. 1 mitosis is seen. No microvascular proliferation or necrosis is present. There is no oligodendroglial component. The features are those of diffuse astrocytoma.

The tumor cells are p53 and IDH-1 positive (mutated). ATRX shows loss of staining (mutated). MGMT is negative (likely methylated). The topoisomerase index is about 3%.

Final diagnose

Astrocytoma, IDH-mutant (WHO Grade 2)

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