Atypical meningioma

Case contributed by Sylvia Okwemba , 10 Apr 2024
Diagnosis certain
Changed by Arlene Campos, 11 Apr 2024
Disclosures - updated 9 Jun 2023: Nothing to disclose

Updates to Case Attributes

Age changed from 63 to 65 years.
Edit Without Moderation was set to true.
Presentation was changed:
Incidental finding of left parietal calcified meningioma on CT following MVA.GCS 15/14. No focal deficits.
Body was changed:

In this case example the low tumoural ADC values and evidence of brain invasion are consistent with reported imaging findings of atypical meningioma which was confirmed on tumour resection.

Histology courtesy of Dr. S Roberts-Thomson, Royal Melbourne Hospital, Australia.

  • -<p> In this case example the low tumoural ADC values and evidence of brain invasion are consistent with reported imaging findings of atypical meningioma which was confirmed on tumour resection. </p><p>Histology courtesy of Dr S Roberts-Thomson, Royal Melbourne Hospital, Australia. </p>
  • +<p>In this case example the low tumoural ADC values and evidence of brain invasion are consistent with reported imaging findings of atypical meningioma which was confirmed on tumour resection.</p><p>Histology courtesy of Dr. S Roberts-Thomson, Royal Melbourne Hospital, Australia.</p>

Updates to Study Attributes

Findings was changed:

Formalin fixed paraffin-embedded tissue after a left parietal craniotomy and tumour resection.

Description: The tumour shows meningothelial architecture in areas and fascicular in others infiltrating to the fibrous stroma (transitional type). There are multiple foci of psammomatous calcification. The cells show moderate variation in nuclear size with frequent nuclear pseudoinclusions. There is no sheetlike architecture or necrosis. Mitotic activity is infrequent with 1 mitosis identified per 10 high-power fields.

In one fragment, peripherally there is glial tissue which is focally infiltrated by meningioma. Multifocal infiltration is confirmed on synaptophysin immunohistochemistry.

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