Autosomal dominant polycystic kidney disease with hepatic involvement

Case contributed by Mohammadtaghi Niknejad
Diagnosis certain


Abdominal discomfort.

Patient Data

Age: 45 years
Gender: Female

There are enlarged kidneys with numerous cysts. The liver also contains numerous cysts with different sizes. Several tiny cysts also are seen in the peripheral zone of spleen parenchyma.

Case Discussion

Features are consistent with known autosomal dominant polycystic kidney disease (ADPKD), a hereditary form of adult cystic renal disease

Cysts in other organs in a patient with ADPKD :

  • liver: most common, 75% by age 60 years 
  • seminal vesicles: 60% by age 40 years 
  • prostate: 11%
  • pancreas: ~10%
  • spleen: ~5 %
  • ovaries

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