Pain in hips and knees.
Tc 99m MDP bone scan
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NM Isotope Bone Scan.
Focal and discreet areas of increased isotope activity are noted in both femoral heads and in the region of the tibial plateau on both sides
The renal transplant is visualised in the right iliac fossa and the bladder contains isotope.
In a renal transplant patient the findings are in keeping with avascular necrosis
Avascular osteonecrosis (AVN) is a serious osseous complication after renal transplantation. Bone scintigraphy and MRI are both useful in the detection of early osteonecrosis after renal transplantation.
Bone scintigraphy is quite sensitive (~85%) and is the second option after MRI. It is a choice when multiple sites of involvement must be assessed in patients with risk factors. The findings are different accordingly to the time of the scan:
- early disease: often represented by a cold area likely representing the vascular interruption
- late disease: may show a "doughnut sign": a cold spot with surrounding high uptake ring (surrounding hyperaemia and adjacent synovitis)
- 1. Hedri H, Cherif M, Zouaghi K et-al. Avascular osteonecrosis after renal transplantation. Transplant. Proc. 2007;39 (4): 1036-8. doi:10.1016/j.transproceed.2007.02.031 - Pubmed citation
- 2. Ryu JS, Kim JS, Moon DH et-al. Bone SPECT is more sensitive than MRI in the detection of early osteonecrosis of the femoral head after renal transplantation. J. Nucl. Med. 2002;43 (8): 1006-11. J. Nucl. Med. (full text) - Pubmed citation