Q: Sickle cell disease can result in what types of musculoskeletal manifestations? show answer
Avascular necrosis of bilateral femoral heads
Difficulties ambulating due to bilateral hip pain for the previous 10 months that has led to the use of a wheelchair due to the inability to walk more than a short distance; past medical history of rheumatoid arthritis and sickle cell anemia
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Avascular necrosis involving both femoral heads is seen depicted by a region with a hypointense serpiginous peripheral rim and inner hyperintense area on T2WI. Double line sign is also seen on axial STIR images in the sacrum on the left side.
The findings seen in this case in a patient with past medical history of sickle cell anemia and difficulties ambulating due to bilateral hip pain is consistent with avascular necrosis of both femoral heads.
Case courtesy of Dr Guillermo Bolivar
- Ejindu VC, Hine AL, Mashayekhi M, Shorvon PJ, Misra RR. Musculoskeletal Manifestations of Sickle Cell Disease 1. Radiographics. 2007 Jul;27(4):1005-21.