Band heterotopia

Case contributed by Dr Ian Craven

Presentation

Pharmacoresistant seizures

Patient Data

Age: 8 years
Gender: Female
MRI

There is a symmetrical band of heterotypic cortex within the posterior aspect of both cerebral hemispheres. The overlying cortex appears macroscopically normal.

Case Discussion

Band heterotopia is a condition almost exclusively seen in females. It is linked to the DCX and LIS1 genes and can be seen in association with lissencephaly. This posterior distribution was confirmed to be a LIS1 genetic mutation. This is a relatively subtle example but highlights the importance of high resolution imaging and the inversion recovery sequence to assess for such abnormalities of cortical migration.

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Case information

rID: 78613
Published: 7th Jun 2020
Last edited: 8th Jun 2020
Inclusion in quiz mode: Included

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