Base of skull chondrosarcoma

Case contributed by RMH Neuropathology


Facial numbness.

Patient Data

Age: 68
Gender: Female

A mass is located at the right petrous apex. I has very high T2 signal and enhances vividly. 




The sections show a chondroid tumour. It forms sheets and focally with a lobulated architecture. The tumour is moderately cellular. The chondrocytes show nuclear enlargement, hyperchromasia, angulated nuclear contour and small nucleoli. Mitoses are inconspicuous. The background stroma is myxomatous with areas of necrosis. More mature chondroid matrix is also present. The tumour cells are S-100 and M2A positive. The Ki-67 index is less than 1%. They are CAM5.2 negative. The features are those of grade 2 chondrosarcoma.

DIAGNOSIS: Grade 2 chondrosarcoma.

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Case information

rID: 28125
Published: 12th Mar 2014
Last edited: 22nd Jun 2018
Inclusion in quiz mode: Included

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