Base of skull chondrosarcoma

Case contributed by RMH Neuropathology

Presentation

Facial numbness.

Patient Data

Age: 68
Gender: Female
MRI

A mass is located at the right petrous apex. I has very high T2 signal and enhances vividly. 

Pathology

Histology

MICROSCOPIC DESCRIPTION:

The sections show a chondroid tumour. It forms sheets and focally with a lobulated architecture. The tumour is moderately cellular. The chondrocytes show nuclear enlargement, hyperchromasia, angulated nuclear contour and small nucleoli. Mitoses are inconspicuous. The background stroma is myxomatous with areas of necrosis. More mature chondroid matrix is also present. The tumour cells are S-100 and M2A positive. The Ki-67 index is less than 1%. They are CAM5.2 negative. The features are those of grade 2 chondrosarcoma.

DIAGNOSIS: Grade 2 chondrosarcoma.

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Case information

rID: 28125
Case created: 11th Mar 2014
Last edited: 7th Sep 2015
Inclusion in quiz mode: Included

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