Base of skull chondrosarcoma

Case contributed by RMH Neuropathology
Diagnosis certain


Facial numbness.

Patient Data

Age: 68
Gender: Female

A mass is located at the right petrous apex. I has very high T2 signal and enhances vividly. 




The sections show a chondroid tumor. It forms sheets and focally with a lobulated architecture. The tumor is moderately cellular. The chondrocytes show nuclear enlargement, hyperchromasia, angulated nuclear contour and small nucleoli. Mitoses are inconspicuous. The background stroma is myxomatous with areas of necrosis. More mature chondroid matrix is also present. The tumor cells are S-100 and M2A positive. The Ki-67 index is less than 1%. They are CAM5.2 negative. The features are those of grade 2 chondrosarcoma.

DIAGNOSIS: Grade 2 chondrosarcoma.

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