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Sagittal T1 and axial T2/FLAIR images demonstrate striking right frontal lobe atrophy with the characteristic "Knife blade" configuration of the frontal gyri.
Coronal T2 images best demonstrate the right temporal atrophy with widening of the right Sylvian fissure and collateral sulcus and thinning of the superior/middle and inferior temporal gyri. It is also useful to compared the greater degree of frontal horn dilatation compared to the temporal horn implying greater frontal regional atrophy compared to the medial temporal lobe.
A degree of hippocampi atrophy are present but the overwhelming pattern is the asymmetric right frontotemporal lobe atrophy.