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Breast lymphoma

Case contributed by Fanibeth Valderrabano Benavides
Diagnosis certain

Presentation

Palpable mass in the left breast.

Patient Data

Age: 60 years
Gender: Female
mammography

A. Mediolateral oblique mammogram of the left breast shows an extremely dense, type D (ACR), and a high-density mass with obscured and indistinct margins, located in the upper internal quadrant, posterior third.

B. Craniocaudal mammogram of the left breast shows a high-density mass with obscured margins.

ultrasound

Hypoechoic heterogeneous irregular mass with indistinct margins, anechoic areas, posterior shadow, and internal vascularity.

ultrasound

Core biopsy of the solid irregular heterogeneous mass. 

Nuclear medicine

FDG PET-CT of the left breast located in the upper internal quadrant shows focal hypermetabolism.

Compare with the CT simple, shows a homogenous mass.

Case Discussion

Diagnosis: 

LARGE CELL DIFFUSE NON-HODGKIN LYMPHOMA.

Immunohistochemistry: 

CD 20 Positive

CD 3 Positive

CKAE/AE3 Negative

CKAE/AE3 Negative

CD3 POSITIVE IN REACTIVE LYMPHOCYTES

Breast lymphoma is haematologic cancer and a rare tumour and represents 0.04- 0.7% of all breast. Represents 0.38-0.7% of all non-Hodgkin lymphomas.

This cancer is very aggressive and affects old women 60-85 years. 

Are divided into primary and secondary. The first has many subtypes and the most common is a diffuse large B cell lymphoma approximately 45-79% and Burkitt lymphoma is associated with people VIH +, pregnancies, and women in lactation, and represents only 10%. 

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