Callosal glioblastoma

Case contributed by Dr Maxime St-Amant


Altered mental state.

Patient Data

Age: 59-year-old
Gender: Male

CT Brain

Modality: CT

There is a left temporo-parieto-occipital lesion that transgresses the splenium of the corpus callosum. Associated vasogenic edema +/- cytotoxic edema involving the posterior parietal cortex. The most probable diagnosis is glioblastoma multiforme. There could be an associated stroke-like phenomenon, but it is most probably secondary to the tumor. MRI is suggested to confirm the diagnosis is this examination was realized without IV contrast.

MRI Brain

Modality: MRI

MRI confirms a voluminous, heterogeneous, mass involving the left temporo-parieto-occipital lobes which transgresses the splenium of the corpus callosum. There is a slight extension of the mass into the right occipital parenchyma. The lesion is partly solid, with necrotic & hemorrhagic (see the blooming on T2* GRE) components. Associated local mass effect & edema. The findings are compatible with glioblastoma multiforme.

There is no abnormal leptomeningeal enhancement.

Case Discussion

The diagnosis of GBM was confirm on histology. Other differential diagnosis are less plausible. GBM is the most frequent corpus callosal tumor. Another tumor which can involve the corpus callosum is lymphoma, but it is not hemorrhagic/necrotic like this, and it is hyperdense on CT.

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Case Information

rID: 19254
Case created: 21st Aug 2012
Last edited: 11th Dec 2015
Inclusion in quiz mode: Included

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