Caudal regression syndrome - type 1
Bowel and urinary incontinence since childhood. No limb weakness
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The caudal regression syndrome results from an insult at the early stages of gestation. This is common to infants born to diabetic mothers 1.
Caudal regression syndrome comprises two types.
- type 1:
- characterized by a club-shaped or wedge-shaped conus medullaris abruptly ending above the lower border of the L1 vertebra
- associated with major sacral dysgenesis; in severe cases, the last intact vertebra is at T11 or T12 level 2
- usually presents with motor weakness and/or urinary and bowel symptoms 1
- usually lumbosacral neurological sensation is less affected 1
- type 2:
- characterized by a low-lying tethered cord in which the conus ends caudally to the lower border of L1
- sacral agenesis is usually less severe
- associated with severe neurological disturbances with deterioration 1
Prognosis depends on the severity of the condition and presence of associated anomalies 2.
- 1. Puneeth KT, Goyal A, Jana M. High abrupt cord termination: a hallmark of caudal regression syndrome. BMJ case reports. doi:10.1136/bcr-2013-201770 - Pubmed
- 2. Sharma P, Kumar S, Jaiswal A. Clinico-radiologic Findings in Group II Caudal Regression Syndrome. Journal of clinical imaging science. 3: 26. doi:10.4103/2156-7514.114214 - Pubmed