Central neurocytoma

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
MRI

Although this case demonstrates the typical 'bubbly' appearing lateral ventricular mass, it is somewhat atypical in that most central neurocytomas enhance moderately, whereas this one demonstrates only minimal enhancement. A differential would be a subependymoma. 

Case Discussion

The patient went on to have a resection. 

Histology report

Tumour cells have regular round and oval vesicular nuclei, many with discernible nucleoli and delicate processes. Aggregates of nuclei are separated by fibrillary eosinophilic neuropil-like material. No mitotic figures are identified and there is no vascular endothelial cell proliferation or necrosis.

Tumour cells show strong peri-nuclear granular immunostaining for synaptophysin. No staining for epithelial membrane antigen (EMA) or GFAP is seen in tumour cells and there is no nuclear staining for Ki-67/MIB-1. The features are of central neurocytoma.

Final diagnosis: central neurocytoma.

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Case information

rID: 2590
Published: 7th May 2008
Last edited: 12th Apr 2018
Inclusion in quiz mode: Included

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