Central neurocytoma

Case contributed by Frank Gaillard
Diagnosis certain

Patient Data

Age: Adult
  • Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

Although this case demonstrates the typical 'bubbly' appearing lateral ventricular mass, it is somewhat atypical in that most central neurocytomas enhance moderately, whereas this one demonstrates only minimal enhancement. A differential would be a subependymoma. 

Case Discussion

The patient went on to have a resection. 

Histology report

Tumor cells have regular round and oval vesicular nuclei, many with discernible nucleoli and delicate processes. Aggregates of nuclei are separated by fibrillary eosinophilic neuropil-like material. No mitotic figures are identified and there is no vascular endothelial cell proliferation or necrosis.

Tumor cells show strong peri-nuclear granular immunostaining for synaptophysin. No staining for epithelial membrane antigen (EMA) or GFAP is seen in tumor cells and there is no nuclear staining for Ki-67/MIB-1. The features are of central neurocytoma.

Final diagnosis: central neurocytoma.

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