Central neurocytoma

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult

Although this case demonstrates the typical 'bubbly' appearing lateral ventricular mass, it is somewhat atypical in that most central neurocytomas enhance moderately, whereas this one demonstrates only minimal enhancement. A differential would be a subependymoma. 

Case Discussion

The patient went on to have a resection. 

Histology report

Tumor cells have regular round and oval vesicular nuclei, many with discernible nucleoli and delicate processes. Aggregates of nuclei are separated by fibrillary eosinophilic neuropil-like material. No mitotic figures are identified and there is no vascular endothelial cell proliferation or necrosis.

Tumor cells show strong peri-nuclear granular immunostaining for synaptophysin. No staining for epithelial membrane antigen (EMA) or GFAP is seen in tumor cells and there is no nuclear staining for Ki-67/MIB-1. The features are of central neurocytoma.

Final diagnosis: central neurocytoma.

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Case information

rID: 2590
Published: 7th May 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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