Cerebellar metastases

Case contributed by Dr Lawrence Chia Wei Oh

Presentation

One month of headache with nausea and vomiting. Ataxic gait. Known history of ovarian cancer

Patient Data

Age: 70
Gender: Female
Race: Caucasian
MRI

Enhancing solid cystic mass with peripheral satellite nodules noted in the right cerebellar hemisphere. Small enhancing nodules also noted in the left cerebellar hemisphere. These cause herniation of the right cerebellar tonsil with effacement of fourth ventricle.

Case Discussion

Patient went on to have right posterior fossa craniotomy and resection of metastatic lesion. Intra-operatively, the metastatic lesion was noted to be multilobulated with a cystic component medially.

HISTOLOGY

MACROSCOPIC DESCRIPTION:

Multiple fragments of irregularly shaped light medium brown brain tissue 11g and 50 x 30 x 25mm in aggregate

MICROSCOPIC DESCRIPTION:

Sections demonstrate high grade metastatic carcinoma with a combination of solid and papillary and micropapillary architecture. The malignant cells have markedly pleomorphic nuclei with prominent nucleoli. The cells have a moderate amount of ampophilic cytoplasm with some hobnail forms seen. Areas of tumour necrosis are apparent. The tumour shows a sharp demarcation with adjacent cerebellar tissue

DIAGNOSIS:

Metastatic carcinoma - appearances consistent with origin from a high-grade ovarian serous carcinoma.

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Case information

rID: 24038
Case created: 25th Jul 2013
Last edited: 11th Nov 2015
Inclusion in quiz mode: Included

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