Cerebellar metastasis

Case contributed by A.Prof Frank Gaillard



Patient Data

Age: 80 years
Gender: Male

There is a well defined heterogeneous intra axial mass in the left cerebellar hemisphere. This demonstrates heterogeneous T2 and FLAIR signal - predominantly hyperintense centrally and predominantly hypointense peripherally. Areas of high intrinsic T1 signal centrally and peripheral blooming on susceptibility sensitive sequence suggest the presence of blood products. Abnormal signal on diffusion weighted imaging which is difficult to interpret in the presence of blood products. Heterogeneous enhancement in the mass following contrast administration. Surrounding T2 and FLAIR hyperintensity in the left cerebellar hemisphere extending into the left cerebral peduncle. Minor mass-effect on the left lateral wall of the fourth ventricle but no effacement. Established infarcts in right cerebellar hemisphere.

Periventricular T2 and FLAIR hyperintensity, with multiple foci of T2 FLAIR white matter of both hemispheres and in the pons most in keeping with chronic small vessel ischemic disease. No other parenchymal abnormality or other region of abnormal enhancement.


Well-defined enhancing mass in the left cerebellar hemisphere with intrinsic T1 hyperintensity and blooming on susceptibility sensitive sequence suggesting hemorrhage. Appearance most likely represents a solitary hemorrhagic metastasis. 

Case Discussion

The patient had a prior history of lung cancer (adenocarcinoma) and went on to have surgery.


MICROSCOPIC DESCRIPTION: The sections show a densely hypercellular tumor. Tumor cells have pleomorphic large vesicular nuclei many with conspicuous nuclei and a variable amount of pale cytoplasm and are arranged in solid aggregates. Frequent mitotic figures are identified and there is extensive tumor necrosis. Tumor is sharply demarcated from adjacent gliotic brain parenchyma. Immunohistochemistry shows positive staining with CK7 and BER-EP4. The tumor cells are TTF-1 and Napsin-A negative.

FINAL DIAGNOSIS: Metastatic undifferentiated non small cell carcinoma with features most consistent with an origin from lung.

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Case information

rID: 38835
Published: 15th Feb 2016
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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