Cerebral arteriovenous malformation with lobar haemorrhage

Case contributed by Prof Peter Mitchell

Presentation

Headache and reduced GCS to 11.

Patient Data

Age: 89
Gender: Female

Left frontal lobe intraparenchymal haemorrhage.

Large tortuous vessel over the haematoma and left frontal lobe with focal dilatation. This is consistent with an enlarged vein with venous varix, most probably secondary to an arteriovenous malformation, the major differential diagnosis is a dural arteriovenous fistula with cortical venous drainage and varix (Cognard 4).

Large left frontal intraparenchymal acute haemorrhage (involving the cerebral cortex) measuring 36x36 x33 mm in maximal dimensions of surrounding region of hypodensity compatible with vasogenic oedema.

There is moderate secondary mass effect with compression of adjacent sulci (resulting in crowding of the sulci at the vertex), partial compression of the frontal horn of the left lateral ventricle and mild subfalcine herniation. There is also approximately 3 mm rightward midline shift measured at the septum pellucidum.

No evidence of intraventricular or extra axial haemorrhagic extension. No further evidence of acute haemorrhage. Deep white matter/periventricular foci of low attenuation is compatible with chronic small vessel ischaemia.

Conventional aortic arch anatomy. Bilateral vertebral arteries are of subclavian origin.

Overlying the left frontal and temporal lobes are very large calibre arteries and draining veins (seen draining into the sigmoid sinus on the left and the sagittal sinus superiorly). There is a more focal bulbous aneurysmal dilatation measuring 7x6mm in size overlying the left frontal lobe. Conclusion

Large left frontal intraparenchymal acute haemorrhage measuring 36x36x33mm

in maximal dimension veins with evidence of surrounding vasogenic oedema and secondary mass effect as described above.The CT angiogram study demonstrates enlarged draining vessels overlying the left frontal and temporal lobes (combination of arteries and veins).

Findings are most compatible with an underlying arteriovenous malformation, with suggestion of arterial supply from the left external carotid artery.

An digital subtraction angiogram study is recommended further evaluation.

Superficial pial AVM with rapid arteriovenous shunting, a (predominantly) single draining vein with large venous varicosity.

Note the 4D DSA showing time resolved filling of the vein, varicosity, and showing the associated stenosis.

Case Discussion

Lobar haematoma occurring spontaneously in an 89 year old still most commonly represents hypertensive haemorrhage, or haemorrhage related to underlying amyloid angiopathy. Bleeding diathesis - especially anticoagulation - needs to be excluded. However underlying causes such as tumour, vascular malformation, aneurysm, and venous sinus thrombosis need to be considered even in an 89 year old with hypertension. CT, post contrast CT (looking for "spot sign"), and CTA would have sufficient sensitivity as first line investigations, with catheter angiography or MRI depending on the findings.

Selective DSA with microcatheter was performed, one branch occluded at the nidus, but the diffuse nature of the nidus, multiple "en passant" arterial feeders, and consideration of haematoma removal meant further endovascular intervention was not proceeded with, and surgical evacuation planned.

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Case Information

rID: 44725
Case created: 3rd May 2016
Last edited: 13th May 2016
Inclusion in quiz mode: Included

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