Cerebral metastasis (breast cancer)

Case contributed by A.Prof Frank Gaillard

Presentation

Increasing headache.

Patient Data

Age: 60 years
Gender: Female
CT

CT brain

Single image of non-contrast study and post contrast demonstrate a heterogeneously enhancing right frontal lobe mass with extensive surrounding oedema. The mass has it's epicenter close to the grey white matter junction. It appears a solitary lesion. 

The patient went on to have surgery and excision of the mass. 

Histology

Microscopic Description:

Sections show a malignant epithelial neoplasm composed of cells with large pleomorphic nuclei with frequent mitotic figures and abundant cytoplasm. The cells are arranged in sheets and glandular structures and there is abundant tumor necrosis. The tumor is adherent to and invades into dura matter. Several fragments show the interface between tumor and brain with definite invasion of the neuropil. Tumor is present in all the submitted sections including those marked with ink and sutures.

Final Diagnosis: Metastatic carcinoma.

Case Discussion

This patient has known metastatic breast cancer and is a good example of how cerebral metastases and gliomas can look similar.

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Case information

rID: 5376
Case created: 9th Jan 2009
Last edited: 10th Nov 2015
Inclusion in quiz mode: Included

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