Cerebral venous thrombosis

Case contributed by Dr Lukas Valkovic


28 year old patient treated for ulcerative colitis with verified congenital hypercoagulable condition. After surgery for thrombosed hemorrhoids she started to feel strange with headache and vomiting.

Patient Data

Age: 28
Gender: Female

Complete thrombosis of the right transvere sinus, rectal sinus, right sigmoid sinus and v. magna Galen. Partial thrombosis of the left transversal sinus, superior sagittal sinus and right jugular bulb.

No morphological or functional changes in brain parenchyma.

Case Discussion

Patient surpassed TIA with right-sided hemiparesis in the past, with diagnosis of homozygous mutation in MTHFR (Methylene tetrahydrofolate reductase). The MTHFR gene produces an enzyme that helps regulate homocysteine levels in the body. Disorders in homocystein metabolism are associated with increased risk of vein thrombosis and are connected with vascular wall damage. The exact connection and mechanisms are still not well known.

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Case information

rID: 45678
Published: 24th Jun 2016
Last edited: 26th Dec 2016
Inclusion in quiz mode: Included

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