Cerebral venous thrombosis
28 year old patient treated for ulcerative colitis with verified congenital hypercoagulable condition. After surgery for thrombosed hemorrhoids she started to feel strange with headache and vomiting.
Loading Stack -
0 images remaining
Complete thrombosis of the right transvere sinus, rectal sinus, right sigmoid sinus and v. magna Galen. Partial thrombosis of the left transversal sinus, superior sagittal sinus and right jugular bulb.
No morphological or functional changes in brain parenchyma.
Patient surpassed TIA with right-sided hemiparesis in the past, with diagnosis of homozygous mutation in MTHFR (Methylene tetrahydrofolate reductase). The MTHFR gene produces an enzyme that helps regulate homocysteine levels in the body. Disorders in homocystein metabolism are associated with increased risk of vein thrombosis and are connected with vascular wall damage. The exact connection and mechanisms are still not well known.
- Varga EA, Sturm AC, Misita CP, Moll S. Homocysteine and MTHFR Mutations. Circulation. 2005; 111: e289-e293
- Dayal S, Chauhan AK, Jensen M, et al. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood 2012;119(13):3176-3183.
- Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost. 2005 Feb;3(2):292-9.