Choroid plexus papilloma

Case contributed by Frank Gaillard


Headache, nausea and vomiting.

Patient Data

Age: 65 years
Gender: Female

A vividly enhancing mass in the 4th ventricle is present, with speckled calcification. It is a solitary lesion, and no hydrocephalus is present.  



A 17 x 16 x 17 mm mass is seen within the floor of the fourth ventricle. No extension into the foramen of Luschka. It is isointense to parenchyma on T1, T2 hyperintense, and mildly hyperintense on FLAIR, with vivid diffuse contrast enhancement. No diffusion restriction. No foci of hemorrhage seen on EPI, although there are areas of linear hyperdensity on CT that may represent calcification.

No hydrocephalus seen.

Perfusion study demonstrates increased cerebral blood flow within the mass. MR spectroscopy  (not shown) over the mass demonstrates slight reduction in NAA and reversal of the choline to creatinine ratio, although unfortunately a sloping baseline reduces specificity of findings.

T2/FLAIR white matter and periventricular hyperintensity in keeping with chronic small vessel ischemic change. Fluid seen within the ethmoid and sphenoid sinuses.


Tumor within the floor of the fourth ventricle. Given the CT and MRI appearances the differential includes ependymoma, more likely (given the vivid enhancement) a choroid plexus papilloma. Less likely possibilities include a metastasis, or even less likely intraventricular meningioma. 

Case Discussion

The patient went on to have a resection. 


MICROSCOPIC DESCRIPTION: Paraffin sections confirm the frozen section diagnosis of choroid plexus papilloma. The consist of fragments of delicate papillary structures with fibrovascular cores covered by a single layer of cytologically unremarkable choroid plexus epithelium. No mitotic figures, solid papillae or areas of necrosis are identified. 


Choroid plexus papilloma.

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