Clear cell chondrosarcoma (humerus)

Case contributed by Dr Yair Glick


Left shoulder pain for 3 years.

Patient Data

Age: 50 years
Gender: Female

Shoulder X-rays 3 years prior

Wel-defined osteolytic lesion involving the left humeral head and neck. There is a sharp demarcation line with the healthy bone. The lesion erodes the endosteum and invades the joint medially. No periosteal reaction detected. Pathological fracture through the distal third of the lesion.


Recent shoulder X-ray

After having been left undiagnosed - and therefore, untreated - for almost 3 years, the lesion has expanded considerably, with nearly complete destruction of the proximal third of the bone and expansive soft-tissue fullness.

Large, heterogeneous, relatively low-density mass lesion in the humeral head with foci of calcification, mostly at its periphery. The lesion breaks through the bone circumferentially, involves the glenohumeral joint, and displaces the nearby muscles with loss of the intervening fat plane. Its low density is suggestive of a chondroid matrix.

There is a non-enlarged, rounded, axillary lymph node lacking a fatty hilum - cannot be ruled out as pathological.

Case Discussion

Based on its radiological appearance and relatively slow growth, the lesion is most compatible with clear cell chondrosarcoma.

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Case information

rID: 63104
Published: 14th Sep 2018
Last edited: 10th Oct 2018
Inclusion in quiz mode: Included

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