Cloverleaf skull (craniosynostosis)

Case contributed by Aws Qahtan Hamdi


A pregnant woman presented for a routine third trimester obstetrical ultrasound examination.

Patient Data

Age: 30 years
Gender: Female

Cloverleaf/trilobate shape of the skull.

The head is small, with the BPD measurement less than the femoral measurement.

Case Discussion

Cloverleaf skull, refers to a type of severe craniosynostosis which gives the skull a cloverleaf shape.

It is a very rare condition, with less than 130 case reports globally. It results from premature intrauterine closure of the sagittal, coronal and lambdoid sutures, which gives a trilobate appearance to the skull.

It is usually seen in the following conditions:

• thanatophoric dysplasia :classically type II.

• severe Apert syndrome.

• severe Crouzon syndrome.

• Carpenter syndrome.

• Boston-type craniosynostosis.


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