CMV duodenitis: histology
Dyspepsia. Past history of AML with transplant.
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The biopsies of the duodenum shows scattered enlarged cells containing both large intranuclear inclusions and basophilic (more purple) intracytoplasmic inclusions.
While CMV viral inclusions can be seen in enterocytes, they are more commonly identified in endothelial cells or stromal cells. When prominent, enterocyte inclusions should raise the differential diagnosis of adenovirus infection however cells infected with adenovirus should show inclusions restricted to the nucleus and do not show 'cytomegaly' (cell enlargement).