CMV duodenitis: histology

Case contributed by Dr Andrew Ryan


Dyspepsia. Past history of AML with transplant.

Patient Data

Age: 55
Gender: Male

The biopsies of the duodenum shows scattered enlarged cells containing both large intranuclear inclusions and basophilic (more purple) intracytoplasmic inclusions.

Case Discussion

While CMV viral inclusions can be seen in enterocytes, they are more commonly identified in endothelial cells or stromal cells. When prominent, enterocyte inclusions should raise the differential diagnosis of adenovirus infection however cells infected with adenovirus should show inclusions restricted to the nucleus and do not show 'cytomegaly' (cell enlargement).

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Case information

rID: 27528
Published: 6th Feb 2014
Last edited: 26th Mar 2018
Inclusion in quiz mode: Excluded

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